Bacteriophage therapy has been proposed as an alternative novel treatment modality to address the global health threat of antimicrobial resistance. However, similar to antibiotics, bacterial pathogens develop resistance against bacteriophages. In this project we propose to experimentally characterize evolutionary trade-offs of resistance which can be exploited to restore treatment sensitivity of pathogens. Using an innovative mathematical model we translate the obtained experimental data into novel phage-antibiotic combination treatments which can reverse antimicrobial resistance.