Sterilization process failures may place patients at risk; therefore all sterilization procedures must be validated. For steam sterilization, chemical indicators form the first base of judgement for a successful sterilization. In a recent study, the standard chemical indicators are deemed not adequate. Additionally, current commercial indicators (Type 5 or 6) have a significant cost which means that in practice often less secure, lower-class indicators are applied. We developed chemical indicators that simultaneously track temperature and steam conditions over time. The production method relies on an ink which allows for high-throughput production of reliable type 5 or 6 steam sterilization indicators.