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Our brain is an enormous factory, with proteins and protein complexes executing various processing and maintenance jobs. How they work, and why they sometimes make mistakes, depends on their complex 3D structures and intricate adaptations to specific job descriptions. The researchers will reconstruct important proteins in 3D using advanced electron microscopy and data processing tools tol help to gain insight into the important protein machinery of the brain, and – eventually - to develop new therapeutics for neurological disorders.
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