Bringing together the fields of hydrodynamics of complex fluids and microgravity physics, this project targeted the foundations needed to design and test soft matter printers for low and zero gravity conditions. To this end, we constructed an experimental setup. We then used ZARM’s drop tower facility in Bremen for microgravity conditions. We systematically studied the spreading of complex fluids on surfaces with and without gravity. Such results are essential to construct optimal fluid-based systems such as 3D printing in space. Our experiments also provide unique results where multiple theoretical and computational studies can be tested.