Efficient reprogramming of human placental cells for stem cell therapies
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Stem cell therapy offers therapeutic opportunities for diseases such as leukemia and diabetes, during which disfunctioning or diseased cells are replaced with healthy cells. For these therapies, a promising stem cell source which does not require invasive procedures and/or elicit ethical debate are trophoblast cells retrieved from the placenta after birth. However, methods to efficiently reprogram these cells to pluripotent stem cells to enable directed differentiation to any cell type of interest are currently lacking. Therefore, we aim to identify small-molecule compounds that enable efficient reprogramming as critical step towards using placental cells for stem cell therapies.
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