Dietary stimulation of aberrant peptides as a tool to enhance anti-tumor immunity
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A diet for a stronger immunotherapy Immunotherapy is mostly only effective in tumors with a high load of genetic mutations. We showed that amino acid deprivation of cancer cells generates proteins with altered sequences. However, these proteins remain intra-cellular and are blocked from further processing into peptides for presentation to the immune system. This proposal aims to identify genetic and chemical tools that can release this block and allow presentation of altered peptides in cancer cells treated with amino acid deprivation. Successful research will open up possibilities of using diet to improve immunotherapy treatment of cancers with low mutational burden.
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