Paving the C1 route: targeted genome engineering for synthetic one-carbon assimilation
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Methanol and other ‘1-carbon molecules’ are ideal sources for the production of biochemicals and biofuels. Unfortunately, microorganisms suitable for biotechnological production, such as Escherichia coli, cannot grow on these sources. The researcher will engineer possible genetic mutations in E. coli for eating one-carbon substrates, and learn which mutations are important.
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