Skin cancer is the most common type of cancer. Topical treatment by applying creams on the cancerous skin is the most gentle choice especially in the facial area where we want to avoid surgical scars. I propose a new strategy where specific antibiotics increase the efficiency of topical anticancer drugs. The selected antibiotics change structure and fluidity of the membranes of bacteria. Here, I use these antibiotics to change structure and fluidity of cancer cell membranes. The anticancer drugs can be more effectively transported into the cancer cells, which leads to enhanced efficiency of anticancer creams in clinical use.