Energy Heist: How Cancer Steals CAR T Cell Power During Attack
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CAR T-cell therapy is a form of cancer therapy, which uses genetically modified (immune) T cells to kill cancer cells. If successful, it is curative, unlike other therapies. Failure occurs, often due to T-cell exhaustion. This can be linked to mitochondria, the energy factories of a cell, that can be hijacked by cancer cells . This leads to energy depletion and impaired killing. This study aims to investigate whether mitochondrial transfer occurs when CAR T cells and cancer cells interact, and how this impacts CAR T cell function..
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