Our planet is changing rapidly. To understand and forecast how ecosystems are affected by global change, ecology should become a predictive science. We will build a unique virtual research environment that will facilitate this transformation, capitalizing on recent advances in Big Data science. This will enable ecologists to link scattered long-term data on plants, animals, and the environment; share methods for data analysis, modelling, and simulation; and build digital replicas of entire ecosystems (“Digital Twins”). This will transform our ability to understand and predict how ecosystems will respond under different scenarios and mitigation measures, fostering scientific breakthroughs and societal impact.