Viral hijacking of lipid droplets and neutral lipid metabolism for replication organelle formation
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Viruses employ the host to make new viral particles. Enteroviruses such as poliovirus, coxsackievirus, and rhinovirus hijack cellular proteins in order to build replication organelles, the “virus production factories”. Lipids are critical components of these. We discovered how viral proteins (2B, 2C, and 3A) commonly manipulate the cellular lipid machinery to build replication organelles. Moreover, we identified an inhibitor specific to viral 2C that inhibits replication. In addition, we have obtained a detailed inventory of virus infection changes the abundance and activity of cellular proteins, thereby adjusting a cell to the needs of the virus.
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