The long term performance of implantable medical devices such as breast implants, biosensors, pacemakers and drug/cell delivery devices is hindered by complex and unpredictable foreign body responses (FBR). Modern soft robotic technologies can be employed to design sophisticated anti-fouling implants that can remain in the body for an extended period and as well mitigate FBR. In this project, we propose to design a Hybrid Soft Robotic Implant (HyBORG), which employs mechanical oscillation to modulate FBR by altering fluid flow and cellular activity at the implantation site and support long-term functionality of the implant.