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Time-resolved dynamics of glutamate transporters

assignment_turned_inproject01 Jun 2020(Started)-31 Oct 2023(Ended)Closed
Funder: Netherlands Organisation for Scientific Research (NWO)Project code: OCENW.KLEIN.141
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Time-resolved dynamics of glutamate transporters

Description

In this study we will record a molecular movie about changes that take place in a protein, which is essential for the normal function of signal transmission in our nerves. This will be done by combining advanced time-dependent crystallography (which allows observations of movements for single atoms) and recent advances in photopharmacology (which provides prototypes of future drugs that can be activated by light). The resulting film will help to understand how these proteins work and will also help to develop such photoactivatable drugs.

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Rijksuniversiteit Groningen, Faculty of Science and Engineering (FSE), Biochemie , Rijksuniversiteit Groningen , Rijksuniversiteit Groningen
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argos Start a new DMP in Argos
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