Dengue virus disease on a chip for novel biomarker discovery and drug screening
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In the tropics, 50 million people get infected every year with the deadly Dengue virus. 500,000 of them develop hemorrhagic shock syndrome, an often-deadly condition with no cure. With climate change, this disease will become a major global issue. We lack animal models for this disease and thus no treatment has been developed. In this proposal, we aim to develop the first organ on chip model for dengue fever and its accompanying hemorrhagic shock syndrome, which will serve as a platform for novel biomarker discovery, and more targeted treatments.
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