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Rewriting Fear: A novel approach to prevent fear relapse

Funder: Netherlands Organisation for Scientific Research (NWO)Project code: 406.XS.24.03.034
Funded under: SGW Open Competitie XS 2024 - ronde 3

Rewriting Fear: A novel approach to prevent fear relapse

Description

Anxiety-related disorders involve overwhelming fear of harmless situations due to deeply rooted pathological threat beliefs. While exposure-based treatments can effectively reduce such fear in the short-term, one-fourth of clients experience a relapse of fear. This occurs because extinction learning, the core of exposure-based treatments, does not erase the original threat belief. Recent rodent research shows that a gradual extinction learning protocol may directly overwrite the threat belief, preventing fear from returning. This project will be the first to adapt this novel approach for humans and test its effectiveness, aiming to improve long-term treatment outcomes for anxiety-related disorders

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