NANOSPRESSO-NL: Local preparation of high-quality, personalized nucleic acid nanomedicines
Universitair Medisch Centrum Utrecht, Divisie Laboratoria, Apotheek en Biomedische Genetica , Universiteit Leiden, Faculteit der Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research , Karolinska Institute, Medical Biochemistry and Biophysics , Universiteit Twente, Faculty of Science and Technology (TNW), Fysische Scheidingen , Universiteit Twente , Universitair Medisch Centrum Utrecht , Saxion , Universiteit Twente, Faculty of Behavioural, Management and Social sciences (BMS), Health Technology and Services Research , SINTEF, (head-office), Health, Medical Technology , Erasmus Universiteit Rotterdam, Erasmus School of Health Policy & Management ( ESHPM ) , Leiden University , Universiteit Twente, Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS), MESA+ Research Institute for Nanotechnology, BIOS Lab-on-a-Chip group , Universitair Medisch Centrum Utrecht, Wilhelmina Kinderziekenhuis, Laboratorium Klinische Chemie en Haematologie , Universitair Medisch Centrum Utrecht, Wilhelmina Kinderziekenhuis, Metabole ziekten , Universitair Medisch Centrum Utrecht , Universiteit Utrecht, Faculteit Bètawetenschappen, Departement Farmaceutische Wetenschappen, Pharmacoepidemiology & Clinical Pharmacology , SINTEF , Karolinska Institute , Universiteit Utrecht , Universitair Medisch Centrum Utrecht, Wilhelmina Kinderziekenhuis
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Universitair Medisch Centrum Utrecht, Divisie Laboratoria, Apotheek en Biomedische Genetica , Universiteit Leiden, Faculteit der Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research , Karolinska Institute, Medical Biochemistry and Biophysics , Universiteit Twente, Faculty of Science and Technology (TNW), Fysische Scheidingen , Universiteit Twente , Universitair Medisch Centrum Utrecht , Saxion , Universiteit Twente, Faculty of Behavioural, Management and Social sciences (BMS), Health Technology and Services Research , SINTEF, (head-office), Health, Medical Technology , Erasmus Universiteit Rotterdam, Erasmus School of Health Policy & Management ( ESHPM ) , Leiden University , Universiteit Twente, Faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS), MESA+ Research Institute for Nanotechnology, BIOS Lab-on-a-Chip group , Universitair Medisch Centrum Utrecht, Wilhelmina Kinderziekenhuis, Laboratorium Klinische Chemie en Haematologie , Universitair Medisch Centrum Utrecht, Wilhelmina Kinderziekenhuis, Metabole ziekten , Universitair Medisch Centrum Utrecht , Universiteit Utrecht, Faculteit Bètawetenschappen, Departement Farmaceutische Wetenschappen, Pharmacoepidemiology & Clinical Pharmacology , SINTEF , Karolinska Institute , Universiteit Utrecht , Universitair Medisch Centrum Utrecht, Wilhelmina Kinderziekenhuis
NANOSPRESSO-NL specifically addresses the current mismatch between personalized therapeutic strategies and industrial centralized large-scale manufacture of medicines. The NANOSPRESSO-NL consortium is convinced that nucleic acid therapeutics are uniquely qualified for production in local hospital pharmacies in response to the needs of the individual patient. By switching towards a fully standardised platform formulation, quality control can be centred around the production process rather than the end product, quite similar to a popular method of decentralized high-quality espresso making.
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