Understanding cancer formation: a ground-breaking model of esophageal stem cells
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The tube connecting the throat with the stomach is called the gullet. Cancer of the gullet does not just appear. Years before cancer appears, the mucous membrane of the gullet changes form. This new mucous membrane is called ‘metaplasia’. We do not yet understand where metaplasia comes from. The gullet has glands where metaplasia might come from. In this project, I will make the first-ever 2D model of these glands of the gullet. By understanding where metaplasia of the gullet comes from we can eventually learn how to prevent metaplasia and cancer of the gullet.
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