Detoxification of substance use is an important step in addiction recovery. Patients often prefer detoxification within their own living environment. To facilitate safe and comfortable outpatient detoxification, close monitoring and rapid medical response are essential to mitigate severe withdrawal. Detox@Home supports this with a digital platform for self-report measures, telemonitoring of withdrawal severity, communication with therapists and eHealth support. We investigate patients’ and clinicians’ support needs during detoxification, build a digital platform and test this in clinical practice. Our team with patient representation, clinicians, researchers, a healthcare insurer and technological company ensures an efficient, safe and accessible outpatient detoxification.