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A breakthrough discovery in 2000 that fear memories may change upon retrieval - known as memory reconsolidation - opened avenues to develop a revolutionary new treatment for emotional memory disorders. Over the past years we have repeatedly demonstrated in humans that disrupting memory reconsolidation erases the expression of fear memory, without changing the actual recollection. Although these findings suggest the possibility of a paradigm shift in clinical practice, a reconsolidation intervention for excessive fear memories has not left the hypothetical arena. This project aims to further understand how we can reset fear memories in patients with anxiety disorders and PTSD.
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