Implants often trigger inflammatory responses that current materials can only partially counteract. Our research introduces materials that influence energy production in immune cells. These innovative materials release metabolic inhibitors when inflammatory cells degrade the material — the stronger the inflammatory response, the more inhibitors are released. This self-regulating system not only suppresses inflammatory cells but also transforms them into cells that promote tissue repair, shifting the implant–body interaction from conflict to coordinated healing. With this concept, we lay the foundation for a new generation of implants that actively support tissue regeneration.