Can language help to solve communication challenges in consultations with patients presenting medically unexplained symptoms (MUS)? These symptoms are serious and not well understood. Although scholars have repeatedly ascertained the importance of doctor-patient interactions for establishing and handling MUS, previous research failed to involve a linguistic account of communication. This project will strengthen the link between medical and linguistic research on communication to define what good communication in terms of language encompasses. Medical research indicates that positive wordings would have therapeutic effects, but studies merely compare effects of messages with different contents (e.g. “it will sting a little bit” versus no warning message for medical procedures). Message content (what is said) and language (how it is said) are not distinguished. Yet, subtle language differences affect patients’ emotions and cognitions and thereby their quality of life and wellbeing. The aim of the proposed project is twofold. First, to capture how key linguistic elements are constructed during GP-patient interactions. Second, to analyse psychological mechanisms of language use variations affecting medical outcomes. The project will build towards a model that defines working mechanisms of language in medical interactions. Results will help to understand the construction and effects of language use in general practice consultations and will provide input for GP guidelines and education on what (not) to say.