Exercise is a great medicine to improve health and reduce the risk for cardiovascular diseases. However, high-volume high-intensity exercise training can acutely damage cardiac tissue, whereas prolonged exercise training may induce scar tissue. It is unknown how exercise may induced these deleterious effects, and these processes cannot be assessed in human and animal studies. Therefore, we aim to develop a unique exercise-on-a-chip model by exposing cultivated heart cells to simulated exercise conditions. This novel model would be a big step towards unravelling how extreme exercise may hurt the heart, and what can be done to avoid such side effects.