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GENOMICS AND MOLECULAR EPIDEMIOLOGY OF HUMAN PARAMYXOVIRUSES IN CROATIA

Funder: Croatian Science Foundation (CSF)Project code: IP-2013-11-6255
Funder Contribution: 990,000 HRK

GENOMICS AND MOLECULAR EPIDEMIOLOGY OF HUMAN PARAMYXOVIRUSES IN CROATIA

Description

The family Paramyxoviridae harbors a broad spectrum of serious virus pathogens that are of importance to human health and global economics. Paramyxoviruses are RNA viruses with a single-stranded negative sense genome. They have been isolated from a wide variety of species, demonstrating a vast host range and great viral genetic diversity. These ubiquitous pathogens are among the most common causatives of respiratory tract infections and are responsible for a high degree of morbidity and mortality worldwide. The biology of RNA viruses is influenced by their high potential of continuous evolution. Because of the error-prone nature of their RNA-dependent RNA polymerases and large population sizes, RNA viruses show high levels of genetic diversity. Mutations can significantly influence virus biological properties and lead to appearance of new strains. The knowledge of viral evolution depends on the amount of genomic data available for analysis. We propose the research of viral genomics of wild type paramyxoviruses currently circulating in Croatia. It is our goal to increase the number of genetically well characterized paramyxoviral wild-type strains. The proposed work will add to knowledge about paramyxoviral ecology, variability and evolutionary capacities. As molecular epidemiologic monitoring of circulating wild type viruses enables analysis of current relations between existing viral genotypes, it is an invaluable part of virus surveillance and control, facilitating the detection of endemic areas, estimations of vaccine efficacies and predications of possible outbreaks.

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