The “One Comprehensive Research European University” (1CORE) project constitutes the consolidation and further expansion of the 4EU+ ambitions as a European University. By bringing its cooperation to the next level, the Alliance aspires to reinforce its position as a centre of knowledge and research, a stronghold of European values, and an active agent of positive change in its ecosystems and in Europe. To this end, 1CORE addresses 6 strategic dimensions laid down in 4EU+ Mission Statement which conform the holistic concept of 4EU+ model. These dimensions are operationalised in 1CORE specific objectives, namely: i) transform an alliance of 6 partners into 1 European university, with the 4EU+ Association e.V. at the centre; ii) boost 4EU+ Flagships to implement our common approach to an excellent education and research while serving the society by addressing global challenges; iii) consolidate a student-centred educational framework answering the needs of students in terms of skills, equipping them for the labour market and as citizens; iv) foster the sense of belonging to the 4EU+ community, which supports the construction of a multicultural and diverse European identity, by promoting seamless mobility; v) empower all learners through lifelong learning and open education & science practices; and, vi) bring together a new generation of Europeans who are able to cooperate and work within different European and global cultures, in different languages, and across borders, sectors and disciplines.To pursue these objectives, we rely on a methodology implemented across our core 5 work packages, supported by a solid project management and an ambitious communication and dissemination strategy. The latter will ensure that our achievements are widely available to fellow European Universities, policymakers, and other stakeholders, serving as role model to further increase the quality, international competitiveness, and attractiveness of the European higher education landscape.