Transform4Europe (T4E) is a new university alliance of 7 diverse HEIs from across all 4 regions of Europe: Saarland University (DE), University of Alicante (ES), Estonian Academy of Arts (EE), University of Silesia in Katowice (PL), Sofia University (BG), University of Trieste (IT) and Vytautas Magnus University (LT). Strongly embedded in their regions, the T4E partners have come together with a common vision for the future of the EHEA. They are joining forces in a sustainable alliance to educate a new generation of highly skilled European knowledge-entrepreneurs: agents of change with the entrepreneurial, digital and intercultural competencies needed to actively contribute to and shape upcoming transformation processes. To achieve this, T4E will embed this strong transnational network of universities in a network of the surrounding regions, creating an interregional knowledge and innovation ecosystem of which the T4E alliance is the nucleus. Within this interregional innovation hub, students, researchers and regional stakeholders from across Europe will collaborate to generate new practice-oriented knowledge concerning digital transformation and smart regions, environmental transformation and sustainability, and societal transformation and inclusion, jointly driving the development of Europe and the EEA through the regions. Through an ambitious work programme, the alliance strives to create one single European University with joint governance and service structures characterised by a strategic network of the universities and key stakeholders from their surrounding regions, joint challenge-driven academic programmes with embedded entrepreneurial competencies and language-learning, innovative teaching methods and learning environments that reach into the local communities, innovative knowledge-creating formats between students, staff, entrepreneurs and practitioners, seamless and inclusive mobility and a lively European campus spirit.