InfPrev4frica project aims to capacitate Nursing HEIs from SSA, to facilitate the development nursing students competences in healthcare-associated infections prevention and control, in response to the need to improve the quality of healthcare in this area, increasing its safety and effectiveness, one of the world-wide health priorities that gains special importance in this African region. Intervening on education process of the future professionals simultaneously strengthening the link between the academy and present professionals, this project proposes to improve the quality of HE in SSA, enhancing its relevance for the labor market and society, in line with their competences and skills level and potential. To this, an innovative nursing curricula, focused on infection prevention and control, innovating in contents selection and approach, learning objectives and on the improvement of partner's teaching/learning pedagogical methods/tools, will allow the development of high level thinking competences, arising nursing students’ innovative and entrepreneurial spirit. Aligned with the undeniable fact that education of health professionals’ design involves the accordance with the health needs of the society where care is provided, the main outcome of this project is an innovative pedagogical model that formally addresses this scopus in SSA cultural and healthcare reality, as for patient safety to result in safe practice and improved patient outcomes, it has to be meaningful to the students. To achieve this Model, along with innovative methods and tools, namely in simulation-based learning, the project main activities are the design, piloting, evaluating and implementing the InfPrev4frica Model and Simulation Scenarios, resulting in InfPrev4frica E-book. Up to 70 nursing professors, 200 nurses/healthcare stakeholders and 1200 nursing students will be introduce into this new pedagogical conceptions, that will continue to be disseminated by InovSafeCare Community in SSA.