The ENREAC-HEI project is based on a suggestion by the Working Group on Education and Skills under Open Science, that in July 2017 in a report supported by the EU, called ”Providing researchers with the skills and competencies they need to practice Open Science OS”, specifically suggested that “OS skills should become an integral and streamlined component of the standard education, training and career development paths of researchers, and if possible even at earlier career stages, in schools and universities”. In order to support the development of skills and competences in relation to Research Skills and Open Science practices, the ENREAC-HEI consortium, composed of 6 partners coming from 5 EU countries (Cyprus, Poland, Bulgaria, Italy, Portugal) has developed and tested two combined courses on Research Skills and Open Science practices, addressed mainly to HE, BA or MA students to increase their skills and competences in research management, open research techniques, collaboration and teamwork. More than 150 HEI students and experts in all partner countries participated in the project and tested the results. The innovative contents in the ENREAC-HEI program can enable HEI students regardless of discipline, in acquiring autonomy, critical thinking and the capacity for problem-solving to make them more efficient and effective at work, increasing their possibility for employment, succeed in their career and in general being all-around citizens too.In particular, the concrete results of the transnational partnership are: 1) “Essential Research Skills Course”. The course aims at empowering and improving students’ competences in research management, planning, personal effectiveness, collaboration, team-building abilities within a research experience. The course will facilitate students’ success in research, provide them with strategies for the thesis writing process as well as increase their effectiveness in any workplace outside academia. 2) “Open Science Skills Course”. The objective of this course is to provide students with the theoretical knowledge and skills required in order to conduct research activities using Open Science concepts. 3) The ENREAC-HEI Trainer Manual informs and guides the trainers and educators through the process of knowing and understanding the course curricula, their goals and benefits, and gives a vision of the expected profile of the trainers and of the learners. The Manual contains also suggestions for the delivery methodology, guidance on using the Moodle platform, the curricula and a toolbox with complementary activities that can be implemented in the classroom or online through synchronized meetings.4) E-learning Platform for online collaboration to deliver the eLearning courses, manage collaborative work and store data. The educators have complete access to the platform, students’ materials and assessment allowing them to monitor the progress and support their learning process. The project results are available in all partners’ languages and English and are developed in such a way and flexibility to be easy to be updated and transferred in other EU countries in the future. The innovative contents in the ENREAC-HEI program influenced the learners regardless of their academic discipline, in different ways: *Equipped and supported them to be adaptable and flexible in an increasingly diverse, mobile, multicultural and interdisciplinary work environment and society.*Enhanced their skills and expertise regarding research data, data production, management, analysis/ use/ reuse, dissemination of innovative contents.*Increased their performance and efficiency by the development of core transversal skills to keep pace with unpredictable market conditions. *Increased their capacity for professional development and employability skills, problem-solving, communication, and resilience.*Provided a better understanding of the concept of Open Science and increased capacity for professional development for the HEI staff involved in projects and research activities. *Increase the number of undergraduates and master students to get involved in opportunities to help them explore contemporary research problems and develop their research skills to become a researcher. The programme is defined in terms of learning outcomes, which facilitate HE students’ focus on those skills and competences they are about to study and acquire perception on them, forming the basis for their understanding of core topics associated with their academic curriculum.