RUN-EU is a new European University, made up of 8 HEIs from 6 countries and has 75.000 students and 8.000 staff. RUN-EU provides a structured framework for the enhancement of the R&I ecosystem with business and society at a regional and inter-regional level across the University alliance. The proposed RUN-EU+ CSA project primarily focuses on enhancing the development of R&I with and for Society through the development and deployment of collaborative professional practice-based research degrees across the RUN-EU alliance. The main objectives of this CSA project include the: a) Implementation of a common R&I agenda and associated collaborative action plan focused on the strengthening of regional business and society partnerships in R&I across the network which will complement the existing RUN-EU strategic vision for teaching, learning, research and engagement activities, delivering institutional and societal transformation. b) Design and delivery of joint and collaborative accredited professional practice-based research programmes at both masters and PhD level across the RUN-EU alliance in association with industry, business, and societal stakeholders. c) Development and implementation of strategies which enhance the capacity of the human capital engaged in research and innovation, through the development of a collective and collaborative cloud of knowledge portal. d) Mainstreaming of Open Science practices and skills within the RUN-EU R&I platforms, through the delivery of new and innovative programmes aimed at strengthening our commitment to open science principles. e) Contribution to the development of the recently announced ERA Hubs by supporting joint R&I activities across the alliance by supporting the development of the RUN-EU European Innovation Hubs (EIH) and the European Zone of Interregional Development (EZ-ID), with business and societal stakeholders focused on; Future Industry and Sustainable Regional Development; the Bioeconomy and Social Innovation.