Our project “Enhanced networking on antimicrobial resistance surveillance with NGS” brings together Semmelweis University (SU) and Klinika Za Infektivne Bolesti „Dr. Fran Mihaljevic (BFM) with two internationally leading research institutions, Laboratory of Medical Microbiology (LMM), University of Antwerp (UAntwerp) and the Health Research Institute of the Balearic Islands (IdISBa) , on the topic of Antimicrobial resistance surveillance with whole genome sequencing (WGS) in correlation next-generation sequencing techniques. Our aim in AmReSu is to strengthen, to the highest European level, Semmelweis University (SU)’s and Klinika Za Infektivne Bolesti „Dr. Fran Mihaljevic” (BFM)’s scientific excellence and innovation capacity in Antimicrobial resistance surveillance and to set-up an ‘Antimicrobial resistance surveillance vision’ in Hungary and Croatia. Strenghtening antimicrobial resistance (AMR) surveillance is also in line with the Hungarian National Smart Specialisation Strategy and the Croatian National Programe for Antibiotic Resistance Control. AMR bacterial infections are a global threat, they are responsible for increased morbidity and mortality rates in Hungary and Croatia, especially in cases of nosocomial infection. Many previously manageable bacterial infections are becoming increasingly hard to treat. Rising rates of resistance amplify the morbidity and economic burden associated with infections. An estimated 700,000 deaths attributable to AMR every year in the world, and a projected 10 million deaths per year by 2050 in the absence of additional control measures. The core activities of our project are knowledge transfer, exchanges of best practices via a number of institutional networking and training activities, including workshops, conferences, summer schools. to a new level, promoting research excellence in AMR and Microbiome with strong societal impact. Our proposed actions will strengthen joint research programmes in Europe.