The Scientific Foundation of the Spanish Association against Cancer (from now on, FCAECC) is a philanthropic private entity that aims to finance excellent cancer research in Spain for the benefit of the general public and patients. Ranging from basic research to clinical application, FCAECC is the entity that devotes the most funds to promote and support cancer research in Spain. In its Strategic Plan, FCAECC states its firm commitment to finance the best cancer research in Spain, aiming at promoting talent, stabilizing the professional career of researchers, fostering the globalization of Spanish cancer research and involving society. FCAECC has a national fellowship programme that supports experienced researchers to develop their own research lines and currently is funding 525 cancer research projects worth 92 million EUR, which resulted in 316 publications in 2021, with an average impact factor of 8. With AECC Talent new fellowship programme, FCAECC opens its fellowship programme for trans-national mobility, aiming to attract to Spain the most talented experienced researchers from abroad. AECC Talent will contribute to improve prevention, early diagnosis, monitoring and treatment of cancer patients, which are key intervention areas of the Horizon Europe Mission on Cancer. AECC Talent will fund 30 fellowships divided into two calls. Host organisations participating in the programme are accredited by FCAECC as excellent in cancer research by means of a rigorous assessment process that guarantees their quality, impact and leadership in cancer research at national and international level. Fellows will have a wide choice of entities and multidisciplinary teams in which to carry out the project of their interest, following a bottom-up approach. The 15 host organisations report a high number of international collaborations and participation in European and international projects and endorse the principles of the Charter & Code for Researchers.