Modern agriculture is expected to provide ever-increasing amounts of food and feed under uncertain climate scenarios and significant pressure from consumers and regulators for environmentally friendly solutions to combat abiotic and biotic stress associated yield losses. Biostimulants that can improve crop productivity in a sustainable way offer a plausible alternative to the heavily criticized synthetic agrochemicals. To achieve their full potential a science-based understanding of their beneficial effects and avenues for fine-tuning of their bioactivities are of utmost importance. The proposed project will bring together expertise in plant systems biology, chemical biology, as well as biostimulant preparation and characterization, to discover new and optimize existing biostimulants by tapping into innovative sources of natural compounds and integrative biology approaches for elucidating molecular mechanisms underlying stress priming. A global network of leading plant scientists in abiotic and biotic stress signaling from Europe, Africa, and South America, facilitated by an industrial partner specializing in biostimulants production and marketing, will channel their efforts to bring sustainable solutions for crop protection to the farmer. An extensive mobility program will facilitate optimal knowledge-sharing within the network, maximize the research outputs and ultimately lead to increasing the human capacity of the partners.