Proteins, functioning as enzymes, receptors, nanomotors, and transporters, have inspired the creation of numerous artificial molecular systems and materials that mimic biological structures and behaviors. However, replicating their dynamic behaviors and intra-protein communication pathways, which are responsible for allosteric interactions and signal transduction, remains a significant challenge. The "CageComm" project aims to emulate protein-like allosteric interactions and intra-protein communication pathways using multicavity molecular coordination cages. To achieve this, "CageComm" will develop novel directional mechanisms for intra-cage communication, enabling control of one cavity's features through the remote stimulation of another, and integrate them into asymmetric multicavity palladium(II) coordination cages. Like proteins, these coordination cages will be capable of receiving a stimulus, directionally transmitting the signal, and generating outputs such as structural changes, guest binding, or alterations in photophysical and chiroptical properties. Two primary mechanisms for intra-cage communication will be established: guest-induced twisting motion transduction and stimuli-responsive expansion/contraction motion transmission via palladium(II) re-coordination on "gear-like" ligands. Implementing these mechanisms will provide access to advanced features and behaviors of the cages, including structural remote control, remote sensing, cage-to-cage transformations, signal transduction across phase interfaces, and non-linear responsiveness.