The SQUEEZE project aims to improve the treatment and quality of life for patients with rheumatoid arthritis (RA) by maximizing the effectiveness of existing drugs through the use of biomarkers and tailored care. The SQUEEZE project consists of a multidisciplinary team from 9 European countries, including clinicians, healthcare professionals, patient research partners, and scientists. The project's initial findings highlighted the significant differences in the use of disease modifying anti-rheumatic drugs (DMARDs) across European countries, including variations in administration routes, dosages, and accessibility. Such differences often reflect the influence of socio-economic factors, leading to inequalities in treatment standards. We therefore present here SQUEEZE-UP, a proposal that will widen SQUEEZE’s scope by including the expertise of the University of Medicine in Bucharest, Romania. This collaboration will provide insights into the socio-economic context and country-specific strategies for the treatment of RA, and access to patients and clinical cohorts from a distinct socio-economic background. SQUEEZE-UP’s further objectives are to advance the careers of young researchers, enhance the competences and infrastructure of UMFCD, and provide better personalized care tailored to patient needs across Europe. The project will combine large-scale data analysis and prospective studies, and its impact will be seen at the system, organization, and beneficiary levels: increased visibility, economic impact on healthcare systems, access to novel technologies, and positive changes in care models. SQUEEZE-UP will also cover the dissemination, exploitation, and communication of results through various channels, including collaboration with national patient organizations and scientific publications. Overall, SQUEEZE-UP will have a significant impact on the lives of RA patients across Europe and will significantly advance research and innovation in Romania.