DEDALUS will design, develop and demonstrate SSH-driven multi-value energy carrier-agnostic micro (home/apartment)-to macro(building & district-scale) participatory Demand Response (DR) ecosystem, aimed to: (a) facilitate and scale up residential energy consumers massive participation to DR; (b) adapt to a variety of different mono-carrier (electricity, heat) or multi-carrier synergetic scenarios (electricity vs heat and natural gas) at building/district scale, while strengthening social interactions within respective communities. To this aim, we will deploy: 1) a Social Science Framework for multi-dimensional incentives and nudging interventions tools; 2) AI-based individual/building/districts consumers clustering and segmentation algorithms; 3) Open APIs for DR-ready smart appliances; 4) Energy DataSpace adaptation for extended DR interoperability and privacy-preserving DLT/Blockchain Data Governance and flexibility coordination; 5) Digital Twins for consumers-aware DR flexibility planning; 6) Comfort-based flexibility models and tools for serviced apartments for elderly people; 7) flexibility management tools for building and physical/virtual districts energy communities, based on pre-aggregation and shared DR assets; 8) Optimal aggregation of flexible energy assets for district heating and decentralized power2heat 9) Business Sandbox with novel sharing economy social innovation-based business models. DEDALUS solutions will be validated by 5 Front Runners full-scale pilots and replicated by 2 Multipliers in 7 countries, deployed at the interplay of energy, and non-energy (comfort/healthcare, ageing, social innovation) sectors, and operated by different stakeholders (social housing operators, building operators, aggregators, energy communities, retailers/suppliers, DSOs/District Heating Network operators). Capacity building and blueprints will support policy makers and regulators to enable market take-up and EU-wide replication of residential DR.