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The present project is a in line with continuous effort of the partners to provide better insights into the roles and mechanisms of action of CXCL4/CXCL4L1 chemokines and to develop novel tools for the pharmacological inhibition of angiogenesis. The interaction of the Bikfalvi (partner 1) and the Wu (partner 2) laboratory within this project is critical since the Bikfalvi laboratory is able to carry out all the functional studies while the Wu laboratory is an expert in the analysis of protein structure and of interaction studies. This provides an essential add value and synegism for both laboratories for this project. - The project is devided in 3 major aims that include functional studies as well as structural biology studies related to CXCL4/CXCL4L1 chemokines and of pharmacological inhibitors derived from snake venoms. - ...
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