The richness of grapevine (Vitis vinifera) metabolism and its potential for giving rise to an exceptional diversity of flavor compounds contribute greatly to the aromatic complexity of wine. Indeed, analysis of the grapevine reference genome has shown a remarkable expansion of several gene families linked to secondary metabolism, compared to other plants. A striking example of gene family expansion is the terpene synthase (TPS) family that generates aromatic molecules constituting major contributors to wine flavors. Grapevine exhibits the largest TPS family of all plant species for which a genome sequence is available. Interestingly, the expansion of the TPS family in grapevine has been accompanied by a parallel blooming of some cytochrome P450 subfamilies, in particular those recently shown to be involved in the oxidation of monoterpenols. Taking advantage of the availability of several wild and cultivated Vitis genome sequences, the InteGrape project proposes to combine genomic, genetic, evolutionary and functional genomics approaches to investigate jointly the TPS and P450 genes families. This integrated approach will allow us to decipher the evolutionary mechanisms that led to the expansion of these families, to assess the impact of this expansion on the production and diversification of grape berry aroma and to evaluate the potential impact of domestication on the genes involved in grapevine aroma metabolism.