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The impaired skeleton, characterized by an increased fracture risk and compromised bone healing, is a newly recognized and poorly described complication of type 2 diabetes mellitus (T2DM). DIABONE offers a unique perspective to address this issue through seven interdisciplinary work packages. By crossing the boundaries between the fields of bone biology, endocrinology, biomaterials, stem-cell based regenerative medicine and inflammation, DIABONE project will ultimately translate into changes in orthopaedic practice by providing mechanistic-based insights for treating bone fractures and defects of patients with T2DM and establishing the proof of concept for using a customized bone tissue engineered implant tailored to the diabetic host bed. Taking place in nine dynamic and experienced host laboratories composing the consortium,DIABONE aims to catalyse the significant development of early stage researchers by offering these the opportunity to reach a position of professional maturity, diversity and independence in order to enhance their contribution to the knowledge-based European economy and society
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