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Electrical stimulation combined to molecular approach is a promising way for the reformation of damaged neural circuit in the central nervous system after a lesion or a neurodegenerative disease. Placing neural stimulators all along the reforming circuit is certainly key for the complete re-innervation. However, the current tethered neural stimulation technologies do not allow to position the implants over several centimetres in a custom way because of their large spatial clutter. Thus new implantable neurostimulation technologies must be developed to meet this need. In order to fill this gap, the present project suggest to create wireless and battery-free stimulators powered by ultrasound. In order to reach dimensions below 200µm required for intracerebral implants, the consortium will fabricate and use piezoelectric micromachined ultrasonic transducers coupled to stimulating microelectrodes. This new concept of wireless and battery-free electric neural stimulator will be tested in vitro on retinal explants, a gold standard to study axonal regeneration.
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