Controlling fine-scale surface texture is a new frontier for polymer injection moulding. The requested functionalities may be connected with visual or haptic aspects for consumer goods, or with more technical ones such as wetting, adhesive or frictional properties. The biomedical field by itself encompasses a very wide potential of applications for such technologies, with stringent technical specifications on mass-produced consumables. Our choice in TopoInjection is to work on injectable drug delivery devices, to focus on a specific industrial application – yet the results should be widely applicable. Such a system must be able to deliver active biological substances with a high precision, must meet strict requirements on tribological properties, watertightness, chemical stability, biocompatibility, and must be compatible with mass production. A preliminary study of the tribological behaviour of the contact between an elastomer (piston) and a rough surface (body) in a syringe suggested which textures should be ideal for polymer surfaces. The next step is now to be able to manufacture surfaces with a reproducible texture throughout the required scale range (100 nm – 100 µm) on polyolefin pieces produced in large series. The aim of the project is to develop a polymer injection moulding process giving the required textures thanks to a combination of four sets of parameters: 1) the mould surface texture, 2) the mould surface chemistry, 3) the physical and chemical properties of the injected polymer, 4) the injection moulding process parameters. To reach this goal, TopoInjection shall focus on the following keypoints: • develop a new mould surface texturation process, using femtosecond Laser beams; • develop experimental and numerical tools to understand the polymer melt flow at the microscale, together with the evolution of the surface upon unmoulding; • disclose the interactions between the mould surface chemistry, modified by PVD hard coatings, the polymer physico- chemistry and the interface behaviour. This deductive approach will probably not yield all the necessary elements for the solution of the problem. It will therefore be completed by a more inductive, empirical approach based on trials on an instrumented injection moulding press. The results from the deductive approach will be integrated continuously to orient real-size tests. This ambitious project gathers three academic laboratories (LTDS, LaHC, CEMEF-ARMINES), an engineering school (ITECH) and two industrial partners (HEF, Becton Dickinson, HEYRMOULES). Most have both internationally recognised expertise in the scientific fields of interest and a long experience of collaborative projects