Economists, as well as policy-makers, agree nowadays that university-generated knowledge contributes decisively to the economic growth of nations and local economies. The Bayh-Dole Act introduced in the US in the early 80's, was the key policy initiative aimed at encouraging the commercialization of academic research results. Many observers suggest that the recent technological success of the USA owes a lot to this new “commercial model” of university technology transfer. Similar reforms have now been initiated in many advanced countries and most research universities and public research organizations have set up technology transfer offices (TTOs) which commercialize academic knowledge and manage the rights. France in particular, has adopted a series of policy reforms progressively introducing this new model, aiming at improving the social and economic returns of academic research. We show in this proposal, thanks to a first investigation of the French data that we intend to expand and reliabilize in this project, that if public patenting has significantly raised in the last decade (up to 14% of all patent families in 2012), it is mainly due to a sharp modification in the ownership structure of academic patents that is accompanied by a contrasted evolution of their quality indicators. These first results stress a series of interesting questions that we will address in this project. Are traditional academic incentives aligned with this new goal of contributing to technology transfer? Are the different scenarios of technology transfer associated with different levels of effectiveness, and if so, why? What are the impacts of the recent changes of the legislation and of new policy instruments on technology transfer? To answer these questions, we need to rely on a consistent micro-economic understanding of the new commercial model of university technology transfer, at the interplay between the three typical actors of the transfer: the professor (or researcher), the TTO and the company. On the empirics side, we need to rely on very recent, and very complete data. Therefore, we will match, at the professor and researcher level, individual information, patent data, publication data and project funding data. To some extent, France will be considered as a case study in itself. No such precise and complete empirical analysis has already been performed in any large industrialized country. A survey of academic inventors, interviews of TTO CEOs, as well as case studies on the Bordeaux and Strasbourg sites will complement our information when national wide data are not available. So as to contribute to the policy debate on technology transfer, we will identify the impact of policy initiatives which target only some part of the reference population and evidence the differential behavior of “treated” and their controls. We will also expand our investigations to the European level and exploit cross-country policy variations in time. Our goal is to provide robust policy recommendations to improve (tentatively optimize) university technology transfer. The team members are experts on the issue of academic patenting and technology transfer. They are spread over four sites, but many of them have already collaborated in the past. The cohesiveness of the team, including the strong reliability of the connection with the OST (as data provider) will ensure a timely execution of the project. New collaborations will also be undertaken, by matching, in this project, expertises on microeconomic theory, professional practices, applied micro-econometrics, identification techniques for observational data, and different data collection methods. The project should, in addition, significantly contribute to building a strong French research base on university technology transfer, in connection with policy makers, practitioners and students.