The ChanPulse project is dedicated to the development of an innovative class of molecular photothermal transducers for the controlled translocation of ions and water across lipid bilayers. Building on the discovery of artificial ion and water channels, this project focuses on the implementation of two-photon (2P) activated photothermal transducers as synthetic channels. Unlike conventional approaches, the project emphasizes the direct photoresponsiveness of channel constituents, ensuring precision without compromising the integrity of surrounding cell membranes. Temperature modulation, achieved through photothermy, offers a safe and controlled means to influence cellular functions, with potential therapeutic applications. The primary objectives include the synthesis and photophysical characterization of 2P-activated channels, the assessment of translocation through pulsed photothermal gradients in lipid bilayers, and the rationalization of photo-boosted transport through molecular modeling. The project's novelty lies in the creation of self-photothermal synthetic channels, a breakthrough with potential applications surpassing traditional light-activated molecular switches and photothermal nanoparticles. The ChanPulse project is poised to demonstrate the bottom-up formation of nanochannels and their activation through synergistic photothermal and mass transport processes. The anticipated impact encompasses showcasing the ability of photothermal molecules to enhance translocation, revealing transport mechanisms through adaptive artificial channels, and achieving the first active artificial channel capable of generating heat gradients. The ChanPulse project presents a promising avenue for advancing active transport technologies, with far-reaching implications for therapeutic interventions and technological innovations.