MARCEL 2.0 proposes an original concept where metallic nanocatalysts (Au, Ag, Cu nanoparticles) are functionalized with molecular hosting cavities bearing metallic complexes in order to direct the reactivity in ORR and CO2RR electrocatalysis. Both of these processes are complex and require efficient and highly selective catalysts as the metalloenzymes. Inspired form such biological systems whose functioning is based on confinement and supramolecular effects, MARCEL seeks the rational control of forming and stabilizing intermediates to guide specific reaction pathways. This innovative design that relies on surface supramolecular effects will be further combined to plasmonic effect in order to enhance the electrocatalytic performance. The reactivity and interfacial phenomena will be thoroughly investigated by combining experimental (electrochemistry, in situ spectroscopies) and computational analyses.