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While blindness and deafness are widely recognized by the medical community and the society, permanent loss of smell (anosmia), despite being frequent (5% of the global population), deeply altering the quality of life (loss of appetite, social distress) and causing numerous health issues (household hazards, depression, death), did not benefit from much consideration before the COVID-19 pandemic. This disease dramatically increased the incidence of olfactory dysfunction, which is encountered in more than 60% of cases. If most patients recover in a few weeks, about 5 % have still not recovered. Until now, olfactory training has been the only treatment associated with significant benefits for smell recovery, but did not benefit all the patients. Moreover, it is restricted to post-viral anosmia, and there’s currently no treatment for long-lasting anosmia. The DOLFINA project aims to develop an olfactory implant, based on the same concept as the cochlear implant, which has been successfully used to treat patients suffering from deafness. Firstly, we propose to develop sets of electrical stimulation of the olfactory bulb in a rat model that mimics the odorant driven activation of olfactory processing structures by different odorants. Then, we will develop an odorant sensor (electronic nose) able to transform the detection of a given odorant into a specific electrical stimulation. Finally, we will validate the olfactory implant in a rat model, then test it in a sheep model, which is anatomically closer to humans, before its future implementation for the first time in an anosmic patient.
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