Bioinspired microdevices are the prelude to a great advance in biomedical technologies. However, there is a clear gap in fabricating prototypes of the size and complexity of cells. Active colloids are an experimental paradigm to realize microrobots due to their ability to self-propel and perform simple tasks, although they fail to provide autonomous units due to their limited geometries and materials, and lack of autonomy. Conversely, artificial cells capture self-regulated processes reminiscent of their biological counterparts but lack cell-mimetic motion. The creation of autonomous cell-mimetic units combining motion and functionality offers exciting opportunities for the creation of bioinspired microrobots. However, identifying the minimal designs and core elements remains an open challenge. The aim of MIMESYS is to deliver a unique cell-mimetic assembly combining synthetic and biological materials into a motile and autonomous microdevice. This will be achieved by encapsulating enzyme-functionalized active colloids inside giant lipid vesicles (GUVs) into a minimal cell-mimetic architecture. This project provides an experimental model with chemical signals as a behavioural-regulation pathway. The enzymatic particles serve as receiver/sender of chemical signals regulating motion, group dynamics, and functionality; while the GUV acts as an adaptive and permeable container. These units will efficiently navigate complex scenarios, communicate, and perform simple tasks autonomously. MIMESYS will confront the current limitations, leading to a better understanding of the fundamental precursors and conditions to engineer minimal models of motile artificial cells, opening up a new area on biomimicking microdevices. The fundamental outcome of this ANR JCJC project will set the benchmark for future and more complex approaches, addressing gaps in the fields of synthetic biology and active matter.