Effects of drug combinations on HRGβ1-driven tamoxifen-resistant MCF-7 cell growth and invasion

Name: Effects of drug combinations on HRGβ1-driven tamoxifen-resistant MCF-7 cell growth and invasion
Keywords: 3. Good health

appsOther research productkeyboard_double_arrow_right Image 01 Jan 2011Publisher:figshare

Authors: Hutcheson, Iain R; Knowlden, Janice M; Hiscox, Steve E; Barrow, Denise; Gee, Julia MW; Robertson, John F; Ellis, Ian O; +1 Authors

doi: 10.6084/m9.figshare.68791.v1 , 10.6084/m9.figshare.68791

Effects of drug combinations on HRGβ1-driven tamoxifen-resistant MCF-7 cell growth and invasion

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Abstract

Copyright information:Taken from "Heregulin β1 drives gefitinib-resistant growth and invasion in tamoxifen-resistant MCF-7 breast cancer cells"http://breast-cancer-research.com/content/9/4/R50Breast cancer research : BCR 2007;9(4):R50-R50.Published online 8 Aug 2007PMCID:PMC2206726. Growth and invasive capacity of tamoxifen-resistant MCF-7 (Tam-R) cells, on day 7 for growth and on day 3 for invasion, following treatment with either HRGβ1 (10 ng/ml), gefitinib (1 μM), trastuzumab (100 nM), LY294002 (10 μM) or a combination of these agents. Results expressed as the mean ± standard error of the mean of triplicate wells and are representative of three separate experiments. Tamoxifen was present in all studies. *< 0.05, **< 0.01 and ***< 0.001 versus control; < 0.01 and < 0.001 versus HRGβ1; < 0.05 and < 0.001 versus gefitinib + HRGβ1.

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