To secure a continued supply of safe, tasty, affordable and functional/healthy proteins while supporting Net Zero goals and future-proofing UK food security, a phased-transition towards low-emission alternative proteins (APs) with a reduced reliance on animal agriculture is imperative. However, population-level access to and acceptance of APs is hindered by a highly complex marketplace challenged by taste, cost, health and safety concerns for consumers, and the fear of diminished livelihoods by farmers. Furthermore, complex regulatory pathways and limited access to affordable and accessible scale-up infrastructure impose challenges for industry and SMEs in particular. Synergistic bridging of the UK's trailblazing science and innovation strengths in AP with manufacturing power is key to realising the UK's ambitious growth potential in AP of £6.8B annually and could create 25,000 jobs across multiple sectors. The National Alternative Protein Innovation Centre (NAPIC), a cohesive pan-UK centre, will revolutionise the UK's agri-food sector by harnessing our world-leading science base through a co-created AP strategy across the Discovery?Innovation?Commercialisation pipeline to support the transition to a sustainable, high growth, blended protein bioeconomy using a consumer-driven approach, thereby changing the economics for farmers and other stakeholders throughout the supply chain. Built on four interdisciplinary knowledge pillars, PRODUCE, PROCESS, PERFORM and PEOPLE covering the entire value chain of AP, we will enable an efficacious and safe translation of new transformative technologies unlocking the benefits of APs. Partnering with global industry, regulators, investors, academic partners and policymakers, and engaging in an open dialogue with UK citizens, NAPIC will produce a clear roadmap for the development of a National Protein Strategy for the UK. NAPIC will enable us to PRODUCE tasty, nutritious, safe, and affordable AP foods and feedstocks necessary to safeguard present and future generations, while reducing concerns about ultra-processed foods and assisting a just-transition for producers. Our PROCESS Pillar will catalyse bioprocessing at scale, mainstreaming cultivated meat and precision fermentation, and diversify AP sources across the terrestrial and aquatic kingdoms of life, delivering economies of scale. Delivering a just-transition to an AP-rich future, we will ensure AP PERFORM, both pre-consumption, and post-consumption, safeguarding public health. Finally, NAPIC is all about PEOPLE, guiding a consumers' dietary transition, and identifying new business opportunities for farmers, future-proofing the UK's protein supply against reliance on imports. Working with UK industry, the third sector and academia, NAPIC will create a National Knowledge base for AP addressing the unmet scientific, commercial, technical and regulatory needs of the sector, develop new tools and standards for product quality and safety and simplify knowledge transfer by catalysing collaboration. NAPIC will ease access to existing innovation facilities and hubs, accelerating industrial adoption underpinned by informed regulatory pathways. We will develop the future leaders of this rapidly evolving sector with bespoke technical, entrepreneurial, regulatory and policy training, and promote knowledge exchange through our unrivalled international network of partners across multiple continents including Protein Industries Canada and the UK-Irish Co-Centre, SUREFOOD. NAPIC will provide a robust and sustainable platform of open innovation and responsible data exchange that mitigates risks associated with this emerging sector and addresses concerns of consumers and producers. Our vision is to make "alternative proteins mainstream for a sustainable planet" and our ambition is to deliver a world-leading innovation and knowledge centre to put the UK at the forefront of the fights for population health equity and against climate change.

Never before in recorded human history have there been as many extreme climatic events as in the past decade, and anthropogenic climate change is now recognised as a major contributor to this trend. Droughts, floods, cyclones, cold snaps and heat waves are all linked through Earth's climate systems and can have significant ecological and socio-economic impacts on land and in the oceans. Despite growing appreciation of the importance of discrete, extreme events in determining ecosystem structure the vast majority of knowledge stems from terrestrial research, even though marine ecosystems play a central role culturally, socially and economically in the lives of most people. Marine ecosystems provide a myriad of ecological goods and services, including nutrient cycling, food and other resources, biogenic coastal defence and climate regulation, all of which have substantial socioeconomic value. Coral reefs, seagrass meadows and temperate kelp forests are particularly valuable in terms of capital generated from recreation, fishing activities, coastal defence and biodiversity, and contribute trillions of pounds to the global economy each year. In the UK alone, the estimated direct economic value of marine biodiversity exceeds £20 billion per year. In marine environmental research, much attention has been given to ocean acidification and, more recently, plastic pollution, yet there is a strong argument to suggest that extreme warming events (i.e. 'marine heatwaves' (MHWs)) pose an even greater risk to ecosystems. In the past decade alone, MHWs have devastated entire ecosystems and severely affected fisheries, aquaculture, food webs and carbon cycling. The frequency and duration of MHWs has increased significantly in recent decades and is predicted to increase throughout the 21st Century, as a consequence of anthropogenic climate change. Despite the unequivocal importance of MHWs in structuring ecosystems, our current understanding of their impacts remains poor. Knowledge of responses to MHWs stems from only a few events, such as the 1998 El Niño episode, the Mediterranean MHW of 2003 and the 2011 warming event off Western Australia. The 2011 MHW off Western Australia, for example, resulted in major shifts in benthic ecosystem structure in a tropical-temperate transition zone, by causing widespread mortality of cool-water habitat forming species. This project will address critical knowledge gaps in marine climate change ecology. It will synthesise existing information on ecological responses to MHWs and use a novel analytical approach to conduct a global-scale analysis of their impacts. The project will also carry out a range of experiments and surveys to examine how key organisms and processes are affected by MHWs with differing physical attributes. Finally, predictions of future patterns and impacts of MHWs will be made, based on physical and ecological modelling techniques. This project will significantly advance understanding of the impacts of extreme climatic events in the global ocean and will be of direct relevant to climate change mitigation and adaptation, as society must safeguard valuable coastal marine ecosystems against increased climatic stress in the coming decades.

Economic development and population growth in Peninsular India have resulted in rapid changes to land-use, land-management and water demand which together are seriously impacting and degrading water resources. Urbanization, deforestation, agricultural intensification, shifts between irrigated agriculture and rain-fed crops, increased groundwater use, and the proliferation of small-scale surface water storage interventions, such as farm-level bunds (usually to conserve soil moisture in fields) and check-dams (to replenish local aquifers) all have contributed to significant changes in the hydrological functioning of catchments. The impact of such changes and interventions on local hydrological processes, such as streamflow, groundwater recharge and evapotranspiration, are poorly constrained, and our understanding of how these diverse local changes cumulatively impact water availability at the broader basin-scale is very limited. Focussing on the highly contentious inter-state Cauvery River basin (with an area of c.80,000 km2, the Cauvery is one of India's largest river basins) our study addresses the key scientific challenge of representing the many local, small-scale interventions in Peninsular India at larger scales. Using observations from established experimental catchments in both rural and urban settings, the project will first explore how changes in land-use, land-cover, irrigation practices and small-scale water management interventions locally affect hydrological processes. In tandem we will then develop novel upscaling methods to represent the improved process-understanding in models at the larger sub-basin (Kabini, ~10,000 km2) and basin (Cauvery) scales. In so doing, the project will demonstrate the capability to generically represent the cumulative impact of abundant small-scale changes in basin-wide integrated water resources management models. The impact of local-scale interventions will further be modelled alongside projections of population growth, climate- and land-use-change and water demand to assess future impacts on water security across the basin. Key stakeholders are involved throughout the different stages of the project to ensure that project outputs reflect their interests and concerns and provide useful input to their decision making.

With the Kigali Amendment coming into force in 2019, the Montreal Protocol on Substances that Deplete the Ozone Layer has entered a major new phase in which the production and use of hydrofluorocarbons (HFCs) will be controlled in most major economies. This landmark achievement will enhance the Protocol's already-substantial benefits to climate, in addition to its success in protecting the ozone layer. However, recent scientific advances have shown that challenges lie ahead for the Montreal Protocol, due to the newly discovered production of ozone-depleting substances (ODS) thought to be phased-out, rapid growth of ozone-depleting compounds not controlled under the Protocol, and the potential for damaging impacts of halocarbon degradation products. This proposal tackles the most urgent scientific questions surrounding these challenges by combining state-of-the-art techniques in atmospheric measurements, laboratory experiments and advanced numerical modelling. We will: 1) significantly expand atmospheric measurement coverage to better understand the global distribution of halocarbon emissions and to identify previously unknown atmospheric trends, 2) combine industry models and atmospheric data to improve our understanding of the relationship between production (the quantity controlled under the Protocol), "banks" of halocarbons stored in buildings and products, and emissions to the atmosphere, 3) determine recent and likely future trends of unregulated, short-lived halocarbons, and implications for the timescale of recovery of the ozone layer, 4) explore the complex atmospheric chemistry of the newest generation of halocarbons and determine whether breakdown products have the potential to contribute to climate change or lead to unforeseen negative environmental consequences, 5) better quantify the influence of halocarbons on climate and refine the climate- and ozone-depletion-related metrics used to compare the effects of halocarbons in international agreements and in the design of possible mitigation strategies. This work will be carried out by a consortium of leaders in the field of halocarbon research, who have an extensive track record of contributing to Montreal Protocol bodies and the Intergovernmental Panel on Climate Change, ensuring lasting impact of the new developments that will be made.

Human DNA is carried by 23 pairs of chromosomes in every cell of the body, while chimpanzees have 24 pairs. Some deer have three pairs, and some ferns have 600. How and why chromosome numbers change over evolutionary time has always been mysterious. Having different numbers of chromosomes may prevent separate species from interbreeding, or even change the rate of evolution by altering how thoroughly parents' genes are 'shuffled' by sex. The smallest known chromosome number for any species is also the smallest imaginable: 1 pair, found in the jack-jumper ant, Myrmecia croslandi. This is a large, highly aggressive Australian ant with a powerful, occasionally lethal sting. Jack jumper ants are also unusual in that very closely related species have widely different numbers of chromosomes despite being very similar in body size, appearance and behaviour. We are members of an international consortium, led by Chinese researchers, that is currently sequencing the genome of the ant with only one pair of chromosomes as part of the 1000 Genomes Project, which has stated aims to complete the sequencing and assembly of 500 animal genomes by 2012. Data from the Myrmecia croslandi genome project will start to become available within the next year and a full genome assembly is expected before the end of 2011. We want to use this new information as soon as it becomes available, to explore the genomes of closely related ants that have far more chromosomes; in one case as many as 18-32 pairs. Although we know that the ants have different chromosome numbers, we know almost nothing about the genomes that make up these chromosomes. We will address these issues by estimating the genome sizes for the different species and by sequencing the genome of a second species, with many more chromosomes than M. croslandi to allow us to ask: Do ants with more chromosomes have more DNA overall, or do they just divide the same amount into smaller pieces? Do ants with more chromosomes have more 'junk' or repetitive DNA? We will also develop methods which can be used in future work to determine whether ants with different chromosome numbers can interbreed. Ants are highly diverse and important components of almost all land ecosystems and show extremely specialised social behaviour. Our work will increase understanding of the evolution and diversification of the ants, and also of genome and chromosome evolution in other species.