This project will address the problem of the compartmentalized academic study of the diverse Frankish- and Islamic-ruled societies through the first comprehensive study of Christianities in the Middle East. It aims to study the inter-Christian and Christian-Muslim interactions, on the assumption that these interactions contribute to shaping these communities. Although each Church has been partly studied for its own sake, no analysis of the cross-flows between the churches and with the sovereign powers that have ruled the Middle East from the 12th to the 16th c. has yet been carried out. It is time for a comprehensive and connected history of Christianities in the Middle East. Decompartmentalizing historiographies implies reading new archival sources along with known published texts from a connected history perspective and moving the analysis of communities from their centers to areas of contact. Jerusalem, owing to its centrality in terms of archives and practices, will be placed at the heart of the project, in tension with the regional space as a whole. ChrIs-cross has three main objectives: • To integrate the history of Christianities within the Islamicate world by identifying the actors, places and different contexts of exchange, from a bottom-up perspective; • To study the Christian communities of the Middle East at a pivotal moment, that of reconfiguration in confrontation with the progress of Islamization, through the strategies of Christian churches and communities, and the role of local authorities, both Christian and Muslim; • To provide both a global and a local vision of Jerusalem through a survey of the impact of intercommunity relations on the urban transformation, supported by a geographic information system: as a global city, Jerusalem is likely the manifestation of a plurality of interactions between the Christian and Islamic worlds, that provides a key to understanding the growing integration of the Middle Eastern region.

The FAST-LAB -- Certified And Secure Time and frequency transfer -- common laboratory project aims at promoting and shaping the interest of the FEMTO-ST institute and the company Gorgy Timing for developing secure and certified time dissemination systems. Time dissemination has become a requirement for current interactions in a society meeting increased timing pressure in its exchanges. Improving accuracy, traceability and safety has become mandatory for the time references clocking today's rail and air traffic, or in the context of distributed energy production in the context of smart grids. Similarly, we address secure timestamping financial transactions -- with Europe being the first institution to draft a law governing such activities with a time reference (MIFID2) -- as well as synchronizing distributed power generation and high bandwidth communication networks. In these 3 examples, the core information is ``time'' and, within the current deployment framework, security and tracking the timestamp information is only beginning. The broad range of time sources, including historical Very Low Frequency (VLF) sources which are currently neglected considering the ease of use of Global Navigation Satellite System (GNSS) networks, provides means of reducing jamming and spoofing risks. Safety of these critical timing services becomes a need that we address by securing the timestamp exchange (using cryptography and two way interactions between clocks exchanging messages). Making the best use of the sources of time and means of accessing these time representations are on the one hand addressed by combining multiple commercially available sources (GNSS, quartz oscillators) and on the other hand by developing dedicated systems meeting the unique requirements of redundancy (flexible software defined radio receivers able to adapt to jamming sources, composite sources dedicated to time transfer applications, time transfer over optical fibers such as White Rabbit). In this context, securing timestamp servers becomes a mandatory requirement, both against classical technical sources of technical failure and vulnerability as well as against attacks focusing on semantics of secure time data and their spoofing. Gorgy Timing is an innovative family SME, dedicated to time transfer. Providing solution for time dissemination, the company is a European leader by developing tools for secure, certified, precise and traceable UTC time diffusion on a network reaching the customer with an accuracy ranging from the millisecond to the nanosecond. In the framework of these innovations, the company Gorgy Timing wishes to enhance its research and development capabilities on secure time and frequency dissemination with the FEMTO-ST institute -- UMR6174. FEMTO-ST, through its Time and Frequency department, exhibits a long and internationally recognized expertise in characterizing and generating ultra-stable frequency signals. Digital signal processing techniques applied to radiofrequency (RF) signals, derived from software defined radio techniques, for characterizing time and spectral characteristics of oscillators provide the opportunity to bridge the fields of interests of the two partners. FEMTO-ST also provides expertise in the field of cybersecurity through the security test team of the Computer Science department (DISC), hence providing a synergy on the research topics ranging from time-frequency to software security.

Textile industry is facing major challenges. It is one of the most polluting industries, and consumers, as well as European regulations, are pushing for change. Indeed, global demand is changing, and consumers tend to expect more sustainable and smart textiles. Moreover, the EC is committed to a green and digital transition and needs to be more competitive globally. In this context, UPWEARS aims to contribute to structural resource efficiency and a sustainable economy by unlocking the potential of a new generation of biobased and hybrid fabrics for e-textile. UPWEARS e-textile will feature high performance, cost-effective multi-functionality, such as functionalized yarn and fibre, biomimetic fabrics, imbedded electronics and energy sensors. Partners will ensure a reduced environmental impact on the manufacturing value chain and end product – a country cycling suit – fully recycled. UPWEARS development will minimise manufacturing waste thanks to artificial intelligence technology and multiscale testing. It will also reduce chemical utilisation thanks to enzymatic & eutectic green solvents. For this, UPWEARS will: -Create an innovative & sustainable value chain from the native fibre to functional device end-of-life; -Switch from a traditional towards a modern textile fabrication process supporting the textile industry's digital and sustainable transformation; -Eco-design an e-textile for high added-value sportswear applications meeting European consumer's demand and contributing to EU competitiveness. UPWEARS implementation and exploitation will have many environmental, societal and economic impacts. It will contribute to EU policies like the EU Green Deal since it combines electronic devices and natural fibres and works on circularity. Finally, UPWEARS consortium covers the full value chain: formulation, functionalization; e-textile design & production; digital transformation; reliability & durability; industrial validation and recycling & additive manufacturing

The IMPACTS project aims at an ever-increasing integration of modeling, numerics and control design for complex multi-physical implicit systems described by both ordinary and partial differential equations. This integration is achieved considering the novel class of Implicit port Hamiltonian (PH) Systems, analyzing their system properties and developing new dedicated methods for numerical simulation and control design. Implicit PH Systems arise from the modeling of systems with non-local constitutive relations, implicit geometric discretization in time and space or control by interconnection. The methodological contributions of this project will concern the modeling and control of implicit PH systems using irreversible Thermodynamics, geometric numerical methods for space-time discretization and order reduction, canonical implicit discrete-time PH systems and energy-based control design, and in domain/boundary control of distributed parameter systems under implicit interconnections.

Glioblastoma (GBM) remains the most aggressive of all primary brain tumors and no effective treatment is available so far. The recent success of immune checkpoint inhibitors in several cancers paved the way for the rehabilitation of anticancer vaccines. However, critical factors challenge the efficacy of cancer vaccines in clinic, such as the nature of tumor antigens, vaccine design and delivery system as well as tumor-associated immune resistance mechanisms. Our ambition is to develop new vaccine strategies in GBMs by combining multiple approaches to overcome these limitations. First, we will take advantage of the tumor antigen Telomerase reverse transcriptase (TERT), which is a promising antigen target given its high overexpression in many cancers, and especially in GBMs. Second, we will assess 2 recently developed vaccine technologies for TERT delivery: i) messenger RNA-based vaccines, which have gained considerable interest in the field of anticancer vaccine, ii) melanin-based vaccine, which represents a novel generation of vaccine delivery platform. Third, we will evaluate the combination of TERT-based vaccines with therapies targeting GBM-associated immune escape mechanisms such as immune checkpoints and immunosuppressive cells on an orthotopic tumor model. By the end of this project, we will define a new vaccine formulation /protocol, aiming to be translated into a clinical trial in GBM patients. Furthermore, the results obtained in this particular tumor model with these 2 different technologies will be of major interest for further vaccine developments, which go far beyond the glioblastoma field, as it has a transfer potential to many more indications (various cancers, viral diseases, infectious diseases…).