As the built environment continues to face challenges such as climate change, energy consumption, and social inequality, there is a growing need for adopting sustainable building practices beyond energy considerations, encompassing environmental, social, and economic dimensions across the entire lifecycle of buildings. In view of these challenges, WILSON proposes a groundbreaking approach, leveraging semantic data repositories, cognitive digital twins, and decentralized data management to transform building and buildings’ portfolio management. The project aims to enhance sustainability by harnessing cutting-edge technologies and innovative management practices. To achieve it, WILSON main development is focused on a decentralized data mesh architecture that is agnostic to and interoperable with proprietary BMS and Digital Twin Systems. Key objectives include improving building operations, evaluating environmental impact, and enhancing building diagnosis and monitoring. Personalized Data Hubs (PDHs) will connect and integrate all WILSON solutions, adhering to International Data Space (IDS) principles. These solutions will be complemented by an Investment Tool to support decision-making on renovation and RES investments. To maximize its impact across the EU, WILSON will validate and demonstrate its solutions in four large-scale pilots across different European countries. The consortium comprises 16 partners (50% SMEs and industry) with diverse expertise, including research institutions, technological providers, an international Data Association, and finance SMEs. Overall, the project aims to upgrade 200,000 m2 of buildings, reducing maintenance costs by up to 35%. In the long-term, WILSON seeks to ensure Europe's global competitiveness, data sovereignty, and achievement of EU energy and environmental goals by 2050, resulting in a highly energy-efficient and decarbonized building stock.

MyPeBS addresses the crucial and timely question of the future of breast cancer screening in Europe. Indeed current standard mammographic screening, with entry stratified by age alone, has recently been largely questioned. Despite a demonstrated mean 20% reduction in breast cancer-specific mortality, together with reduction of late-stage disease in women older than 50, it is associated with potential harms including false positive recalls and over-diagnosis. Individual breast cancer risk estimation, through models including clinical variables, mammographic breast density and more than 100 genetic polymorphisms, now has substantial clinical and scientific bases. Personalized screening strategies, based on individual risk levels, could potentially improve the individual benefit/harms ratio of screening (earlier cancer detection and less intensive treatments in high risk women, less false positives and over-diagnoses in low risk ones), and increase the cost-efficacy for health insurances. MyPEBS will conduct an international randomized phase III trial to validate this hypothesis. It will primarily assess the ability of an individual risk-based screening strategy to be non-inferior, and possibly superior, to the standard of care screening, in reducing the cumulative incidence of stage II+ breast cancers. The trial, conducted in 5 countries (France, Italy, UK, Belgium and Israel) will include 85000 European women aged 40-70, all followed for 4 years. MyPEBS will also evaluate if an individual risk-based screening strategy, compared with the standard, reduces screening-related harms (unnecessary biopsies, overdiagnoses) in low-risk women, is overall at least as cost-effective as well as more accepted by women resulting in a larger screening coverage. After analyses of all components, the final objective of MyPEBS is to deliver recommendations for the best future breast cancer screening strategy in Europe.

Colorectal cancer (CRC) ranks fourth in cancer deaths worldwide. Between 20% and 30% of patients with advanced CRC have liver metastases (CRLM). Liver cancer ranks second in cancer deaths worldwide, including hepatocellular carcinoma (HCC). Despite recent advances, liver resection offers the only chance of cure for patients with liver metastases. However, the recurrence rate of these tumours is high even after post-resection. The presence of positive margins in the remaining liver after resection correlates with increased local recurrence and decreased overall survival, the only factor where prognosis could be influenced by the performance of surgery. However, at present, the extent of an R-negative status remains debatable and varies widely from one publication to another. Currently, there are radiofrequency ablation studies that, based on preliminary retrospective human clinical trials, are able to correlate an additional coagulation of tumor margins with a reduction on local recurrence. However, there is no prospective and pragmatic controlled study that accurately measures this additional margin and its impact on oncological outcomes. The aim of LIVERATION is to conduct an ambitious, pragmatic multicenter clinical trial with 720 patients with CRLM and HCC at 24 clinical centres in 6 different countries to determine whether additional ablated margin produced by radiofrequency can decrease the recurrence rate and improve patient survival. We will also evaluate the patient-centredness of the intervention and its comparativeness with other therapeutic alternatives in terms of quality of life and patient experience in real-world settings. To this end, the consortium has been formed by highly experienced, highly qualified and multidisciplinary entities to carry out the project successfully. The results will not only have a major impact on a social and scientific level but also on an economic level for the EU. This action is part of the Cancer Mission cluster of projects on ‘Diagnosis and treatment’.

Context of the project:This project seeks to prepare health and social care students for the rapidly changing landscape of health and social practice by creating innovative teaching tools and practices. Transversal skills (TS) are crucial to lifelong learning and essential to promote active and involved European citizenship in civic and social life. International and national agencies have stated the need to shift the focus towards teaching-learning strategies that work on transversal skills throughout the training journey. This is especially relevant in health and social care, where these skills are usually taken for granted. These competencies are also important in tackling gender inequities in health and social care, ensuring that the HE system does not prolong entrenched gender bias. The context of this project is the gap identified in the European Higher Education Area: the lack of implementation of teaching-learning strategies for TS for various reason: 1) absence of a framework that defines the gradation of skills development, 2) lack of systematization of teaching-learning strategies that facilitate the acquisition of TS, 3) lecturers’ perceptions of their lack of resources and teaching strategies for working on TS, and 4) lecturers’ difficulties in assessing the development of students’ TS.Objectives:The main objective is to design, pilot, implement and evaluate teaching-learning strategies and resources for undergraduate and postgraduate training. The resources will address learning outcomes related to critical and creative thinking, interpersonal/socio-emotional and citizen-oriented skills and learning to learn. The two specific objectives are: 1.To promote the development of TS in health and social care students, using innovative strategies such as virtual reality. 2.To enable lecturers to teach, guide and accompany students’ development of TS.Description of activities: The project will include the design (1st year), piloting and training (2nd year), and implementation and evaluation of educational resources (3rd year). The educational resources are the project’s intellectual outputs: 1. Pedagogical framework in which TS are defined and levels of skills development are established. 2. Methodological guide with the most appropriate and innovative teaching-learning strategies to support the development of TS, including an evaluative framework. 3. Toolkit with educational resources to work on TS. 4. Educational resources to improve TS using virtual reality tools.The project includes two intensive programmes for HE learners and two short-term joint staff training events. The activities aim to train students and lecturers and, at the same time, pilot the educative resources created. Multiplier events (one per participating country) will help to disseminate the results and project IOs to other HE institutions and are conceived as co-creation workshops which will gather feedback from relevant stakeholders. Participants and methodology: This set of educational resources will be designed in transnational cooperation and co-creation with all relevant stakeholders: a) students and teachers as a target group that will directly use these resources, b) patients and service-users as final recipients and direct beneficiaries of the actions of future trained professionals; c) professionals who provide contextual knowledge about real daily problems. Results: The results expected during the project and on its completion include: 1.Educational materials and resources to foster students’ development of TS, including virtual reality resources. 2.Capacity building of lecturers to implement the educational resources designed in daily teaching. 3.Training and development of students’ TS. 4.Cross-sectoral coordination and participation of all stakeholders in the co-creation process.5.Internationalization of the participating organizations.Impact and long-term benefits:The project impact and long-term benefits include: 1) improvement in students’ transversal and internationalization skills, 2) increased likelihood of sustainability in students’ future working life, 3) greater self-efficiency and increased willingness to work on TS of lecturers, 4) development of new educational products based on virtual reality, 5) greater incorporation in the curriculum of teaching and evaluation activities related to TS, 6) greater openness of HE institutions to society and local networks, 7) higher level of internationalization and visibility of the participating organizations as well as stronger links between partners, 8) improvements in gender-sensitive indicators both in HE and health and social services.