New approaches are needed to reduce the emission of contaminants of emerging concern (CECs). Some sources contribute strongly to such emissions, which has driven the focus of PRESAGE on innovative decentralized wastewater treatment (WWT), based on anaerobic and aerobic compact systems. An integrated analysis of the behaviour of organic micropollutants (OMPs), antibiotic resistant microorganisms and genes (ARMs/ARGs) and pathogens (viruses and bacteria) will be carried out. This will allow better understanding the relation between the operational parameters of reactors, the microbiological evolution in the system, the removal of OMPs and pathogens, and the development of ARMs and ARGs. The contribution of such a complex mixture on the final effluent ecotoxicity will be assessed. The technologies will be validated at 4 demosites treating black and grey water, and effluents from hospitals and an antibiotic industry, in close collaboration with the industrial sector. This high readiness level anticipates a good impact of project results on wastewater innovation. Experts in the field of advanced WWT, microbiology and ecotoxicology will strongly cooperate and participate in a mobility plan focusing on complementary skills. PRESAGE impacts society and economy, boosting the water industry and protecting the environment from effluent discharges containing CECs. In the proposed treatment strategy a minimum global impact is targeted, preferentially promoting the onsite water reuse.