In the Netherlands, 2,300 women annually face a diagnosis of Ductal Carcinoma In Situ (DCIS) and can progress to breast cancer. However, the majority never will. As harmless and hazardous DCIS cannot be distinguished yet, all women get intensive treatment. So, many women carry the burden of overtreatment without any benefit. To reduce this overtreatment, highly innovative, integrative artificial intelligence will be developed, inspired by how weather forecasting is improving over time. This dynamic DCIS-risk forecasting will prevent needless treatment for women with harmless DCIS, preserve their quality of life, and save €15 million/year health care costs.